Roy Hibbert supplied 12 points and 11 boards, while Lance Stephenson added 15 points for Indiana, which has won five of its last six games.
Indiana led 44-43 at the break but used a 17-0 run in the early stages of the third to pull away. Stephenson had nine points during the surge, which he capped with a jumper to extend the margin to 63-45.
The Pacers took a 75-62 cushion into the fourth, where Mike Dunleavy finished off a 7-2 Chicago flurry to get it within 77-69 with 9:30 to play.
The Bulls, though, never got any closer.
Back-to-back buckets by Luis Scola pushed the advantage back to 83-71 and Indiana cruised to the win from there.
Earlier, Chicago led 23-19 after a quarter of play.