Durant made 12-of-22 shots from the field in pushing the Thunder to their fifth straight win.
It was the final game played in the NBA before the All-Star break and Oklahoma City heads into the showcase weekend tied with Miami for the best record in the league at 27-7. The Chicago Bulls are 27-8.
Russell Westbrook added 19 points and Serge Ibaka had 11 points and 13 rebounds for Oklahoma City.
Kobe Bryant scored 24 for the Lakers, but he made just 7-of-24 from the field. Bryant got to the foul line 11 times and hit 10 of them.