Murphy made the announcement by uploading a video of a credits sequence set to the song "Dead of Night" by Orville Peck.
Culkin is a newcomer to American Horror Story while the others are series mainstays. Paulson and Peters were notably not involved with Season 9 after appearing in every previous season.
American Horror Story, which premiered in 2011, is created by Murphy and Brad Falchuk. Each season has been centered around a new horror theme and setting.
FX renewed the series through Season 13 in January.