Hill, 49, will executive produce the new Scripps series with Pickler, 30, and New York journalist Ben Aaron as hosts, according a press release on Hill's website.
"We will bring a little bit of Southern charm and inspiration to our viewers, alongside insights from top tastemakers and experts in many areas," Hill said in a statement. "Kelly is very much southern while Ben is everything New York -- complete opposites but together their chemistry is magic and our viewers are going to love them."
The yet-to-be-titled lifestyle show will debut Sept. 18 on Scripps-owned stations, and include segments on cooking, gardening, entertaining, home design, beauty and fashion. Former Oprah Winfrey Show executive producer Lisa Erspamer and Sandbox Entertainment CEO Jason Owen will co-executive produce.
"Our vision for this show is to deliver the best of lifestyle content with two very talented and charismatic hosts. We are excited about combining an entertaining show with a unique shop-ability factor -- viewers will be able to buy items they see on set while watching the show," Erspamer said.
Hill also has a joint album and tour with husband Tim McGraw in the works. Pickler last released the album The Woman I Am in 2013, while Aaron, who is married to Good Morning America anchor Ginger Zee, hosts the TV program Crazy Talk.