The pair recently confirmed the end of its marriage after a little more than a year.
E! News reported Depp, 53, has since had the word "Slim," which was printed across the fingers of his left hand, changed so it reads "Scum."
The actor referred to his 30-year-old bride and The Rum Diary co-star as "Slim."
The New York Post said Depp has also covered with a dark ink blot the portrait of Heard in a bathing suit that was briefly etched on his right bicep.
Depp has not publicly discussed his new body art.