José Manuel Guillén (pronounced ; born May 17, 1976, in San Cristóbal, Dominican Republic) is a Major League Baseball outfielder for the San Francisco Giants. The Giants are the tenth team for which Guillén has played since his major league debut in 1997.
Guillén was signed by the Pittsburgh Pirates as an amateur free agent on August 19, 1993. He made his Major League debut on April 1, 1997.
On July 23, 1999, Guillén along with Jeff Sparks was traded to the Tampa Bay Devil Rays for Joe Oliver and Humberto Cota. On November 27, 2001, after two injury-plagued seasons with the Devil Rays, the team released him.