Fifth-seeded Frenchman Fabrice Santoro and sixth-seeded German Benjamin Becker were first-round losers Tuesday at the Open de Moselle.
Top-seeded Croatian Ivo Karlovic advanced but second-seeded Gilles Simon of France was ousted Tuesday at the $540,000 Open de Moselle tennis tournament.
Top-seeded Frenchmen Jo-Wilfried Tsonga and Gael Monfils were first-round winners Monday at the Grand Prix Hassan II in Casablanca, Morocco.
Sixth-seeded Sebastien Grosjean of France beat countryman Paul-Henri Mathieu in straight sets Monday at the Grand Prix de Tennis de Lyon.
Top-seeded Andy Roddick of the United States was among Tuesday's opening-round winners at the Lyon Tennis Grand Prix.
The top four seeds reached the semifinals at an ATP event for the first time in two years Friday at the Tata Open.
Top seed Carlos Moya survived a match point Thursday to make his way to the quarterfinals of the Tata Open.
Spaniard Carlos Moya and defending champ Paradorn Srichaphan of Thailand were among five seeded winners Tuesday in the first round of the Tata Open.
Fabrice Santoro of France was among a handful of unseeded players who advanced Tuesday to the second round at Marseille Open.