Craig Andrew Breslow (born August 8, 1980, in New Haven, Connecticut) is a Major League Baseball relief pitcher for the Oakland Athletics. He throws left-handed, and is considered a lefty specialist.

Through 2008, he held major league batters to a .163 batting average with runners in scoring position (and .116 with two outs and runners in scoring position), and lefties hit only .188 against him, with a .256 slugging percentage.

Breslow was given the nickname "smartest man in baseball" by Minneapolis Star Tribune Twins beat writer La Velle E. Neal III, and Wall Street Journal reporter Jason Turbow wrote: "Judging by his résumé, Craig Breslow is the smartest man in baseball, if not the entire world."