The Washington Post reported a house in Mir Ali was hit with two missiles early Thursday. The initial death toll of eight militants was later raised to 10. A security official in the area told the newspaper the deaths included five Central Asian nationals linked to al-Qaida.
A local tribesman said a mosque adjacent to the house was also damaged.
It was the second drone attack within 24 hours in North Waziristan, a militant stronghold for Taliban and al-Qaida leaders planning attacks in neighboring Afghanistan.
The use of unmanned aircraft to fight terrorism is a source of tension between the United States and Pakistan although Pakistani officials have privately supported the killing of al-Qaida and other militants, the Post said. The Pakistani public sees the drone strikes as an attack on Pakistan's sovereignty.