Enrollment is scheduled to begin Tuesday for the Affordable Care Act, also known as Obamacare, and while Dean was against the program in its early stages, he said he's optimistic.
"There are going to be glitches. None of them, so far, are major," he said during an appearance on CNN's "State of the Union." "I'm very optimistic. I think it's going to be good for the public."
Dean, who has a medical degree, said he believes the health insurance program will take people out of the emergency rooms because they'll now be able to visit a doctor before they get that sick.
He said the program most benefits the people who are against it, those over the age of 55 who have been laid off and can't get rehired because of the added risk on a company's health insurance program.
"So, those people are going to benefit disproportionately. The other people who are going to benefit ... is small businesses, because small businesses are going to dump their employees into the exchange," he added. "I think that's a good thing."