Ronna Romney McDaniel, 39, the mother of two children ages 10 and 8, told the Detroit News it's not the right time for a stay-at-home mother to run for the Senate.
Romney McDaniel's father Scott encouraged his daughter to run after he rejected the possibility of seeking Levin's seat himself.
Her mother and grandmother each ran for the Senate from Michigan but both were unsuccessful.
She told the News that her experience with her mother's Senate bids in 1994 and 1996 showed her the toll a campaign can take on a family.
"It's not the right time to put my kids though something like that," she said.