Webb, who won the Women's Australian Open two weeks ago, had birdies on four of the first six holes of the first round and finished with a bogey-free 6-under-66.
Webb's torrid start included birdies at Nos. 1 and 3 and back-to-back at the fifth and six holes. Those are all pars 4. She added birdies at the par-3 14th and the par-4 16th.
Creamer had all of her birdies in the first 13 holes -- again attacking the mid-range holes. Four of her five birdies were on par 4s. Hedwall birdied the first and seventh holes and pulled close to Webb with three straight birdies over Nos. 14-16.