BenJarvus Green-Ellis led Cincinnati's ground game, picking up 92 yards with a touchdown, and the AFC North-leading Bengals (8-4) forced three turnovers to hold off the Chargers.
A.J. Green made five catches for 83 yards and a score.
San Diego (5-7) fell for the fourth time in five games as Philip Rivers was limited to 252 passing yards on 23-of-37 efficiency with one touchdown and an interception.
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