Flames were visible at the top of the scoreboard as the game was set begin at 7:36 p.m. EDT.
Players stayed off the pitch and the south portion of the stadium was evacuated as the Columbus Fire Department fought the blaze, the team said on its official Twitter feed.
No one was hurt in the fire, which began in the scoreboard's speaker cabinet, Crew President and General Manager Mark McCullers told Fox Sports Ohio. He said power was shut down to the scoreboard and the match would be played without it.
The teams took to the field and began the contest at 8:30, almost an hour late.