Andretti Autosport's Hinchcliffe grabbed the advantage with 25 laps remaining on the 1.8-mile St. Petersburg street circuit and held off defending champ Helio Castroneves down the stretch for his maiden IndyCar victory.
It came in the 32nd career start for the Canadian driver, who became the first from his country to win an IndyCar race since 2007.
Castroneves settled for second while Hinchcliffe teammate Marco Andretti claimed third.
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