Denver went down by 17 points in the first quarter but never trailed in the second half en route to evening its five-game road trip at 2-2.
The Pistons got 20 points from Brandon Knight but it wasn't enough to prevent their second loss in two nights after also falling to Philadelphia Monday.
Jason Maxiell contributed 18 points, six rebounds and six blocked shots for Detroit.
Millions of Getty images now available for free via embed tool
NBC reportedly holds celebs hostage to Jimmy Fallon's show