Ginobili finished with 20 points. Blair added 19 and eight rebounds.
San Antonio bounced back after a home loss to the New York Knicks and improved to 8-2 for the season. The Spurs sport a 68-11 record in San Antonio stretching back to the start of the 2010-11 season -- the best home mark in the NBA during the span.
Denver, meanwhile, dropped a third straight despite 15 points from Danilo Gallinari and 14 from Kenneth Faried.