Perry scored 15 1/2 minutes apart in the first period -- with the second goal coming on a power-play -- to hand the Ducks a 2-0 advantage.
His third marker and 26th of the season came with less than 8 minutes left in the middle frame during another power play, extending Anaheim's lead to 5-1.
Bobby Ryan added a goal and an assist while Jason Blake also found the net for the Ducks, who have won three of their last four games.
Fedor Tyutin led the Blue Jackets with a goal and a helper while Steve Mason stopped 30-of-35 shots for Columbus.
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