Rodgers tossed for 255 yards and a pair of touchdowns and also rushed for a score, connecting on 19-of-29 passes and leading the Packers (2-0) to their fourth straight home-opening victory.
Clay Matthews penetrated the Bills' backfield for three sacks and led a stingy defense that limited Buffalo to 186 total yards.
Bills quarterback Trent Edwards was under constant pressure and was held to 11-of-18 passes for 102 yards. Edwards was also picked off twice as the Bills (0-2) lost their second straight at Lambeau Field.
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