Busch temporarily lost the lead after a late-race restart in which he took four tires while Kevin Harvick took only two and briefly grabbed the top spot.
But Busch charges through the crowd from seventh place, passed Harvick with 25 laps left and finished 2 seconds ahead, capturing his ninth Nationwide Series race of the year.
Jason Leffler ended up in third place, Brad Keselowski finished fourth and pole sitter Trevor Bayne claimed the fifth spot.
Keselowski's fourth-place finish enabled him to increased his points lead over Carl Edwards to 231. Edwards finished 10th Saturday.