Durant shot 12-of-18 from the field and scored six consecutive points in the final three minutes to fend off an Indiana rally down the stretch.
Russell Westbrook scored 19 for the Thunder and collected nine rebounds.
Indiana made a bid for a come-from-behind victory with a 9-point run that cut the Thunder's double-digit lead to 93-92 with 5:15 to play.
The Pacers remained within a possession until the 3-minute mark when Durant hit two field goals and a pair of free throws to give Oklahoma City a 102-94 edge with 51.3 to play.
Durant also had a dozen points in the second quarter to help stake the Thunder to a 53-47 halftime lead.