Artose Pinner carried 13 times for 52 yards for Detroit (2-0).
Ryan Fitzpatrick passed for 111 yards and a score for the Bengals (0-2). Jerome Holt led Cincinnati receivers, catching four passes for 72 yards.
Bengals wide receiver Chad Johnson started, but left the game after he injured his shoulder on Cincinnati's first drive and did not return. Lions' cornerback Brian Kelly hit Johnson as Johnson was going up for a pass, and Johnson came down hard on his left side.
Kelly intercepted Carson Palmer's pass on the play.