LaDainian Tomlinson rushed for 131 yards and a touchdown for Chargers (10-3), who have won seven straight games and lead the AFC West by two games.
Drew Brees was 17-of-23 for 220 yards with two touchdowns and two interceptions for the Chargers, who have won 10 games in a season for the first time since 1994 when the club finished 11-5 and reached Super Bowl XXIX.
Brian Griese was 36-of-50 for 392 yards with three touchdowns and three interceptions for the Buccaneers (5-8), who have lost two of their last three games.
Notable deaths of 2014 [PHOTOS]
Michael Sam cut from the Dallas Cowboys