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"A car that was in front of us, a man gets out and starts screaming, 'you're on fire, you're on fire.' So we're all on the bus and starting to panic," passenger Madeline Halimi told cable network NECN.
The bus pulled to the side of the Massachusetts Turnpike and the 46 passengers evacuated the vehicle just before an explosion, which was caught on camera.
There were no injuries from the blast and a replacement bus was sent to pick up the passengers.
The state Fire Marshal's Office and Massachusetts State Police said the cause of the fire and ensuing explosion is under investigation.
BoltBus driver Nora Pacheco said the work being performed on the bus in Connecticut was related to overheating.
"I tried to make it to South Station but it was impossible," she said.