Heritage Auctions said the gloves from Ali's Feb. 25, 1964, fight -- in which he claimed his first heavyweight championship -- will be among the items sold Feb. 22 as part of the auction house's Sports Platinum Auction Night.
"It's hard to imagine a more important or evocative piece of boxing memorabilia," said Chris Ivy, director of sports collectibles at Heritage Auctions. "Ali is the greatest of all time, no doubt, and these gloves were part and parcel of his first step to sports immortality.
"Only Jackie Robinson could compete with Ali for the title of most influential figure in American sports history," Ivy said. "But not even Robinson can compete with Ali in terms of being beloved internationally. Ali is a figure that transcends boxing or America. He belongs to the entire world."