Edward Duke Rancic was born Wednesday, People.com reported.
The birth to a gestational surrogate means the baby is the Rancics' genetic offspring.
"The 'Duke' has landed! Edward Duke Rancic was welcomed into the world last night at 7lbs 4oz," Bill Rancic tweeted. "G & I feel blessed beyond words...We did it!"
Giuliana has suffered numerous health issues in recent years. She had a miscarriage in 2010, underwent fertility treatments to try to get pregnant again, then had a double mastectomy last year as part of her treatment for breast cancer.
The Rancics star on Style Network's, "Giuliana & Bill."