Gugino has appeared in the "Spy Kids" movies, as well as the films "Sin City," "Watchmen" and "American Gangster," and TV's "Spin City" and "Entourage." She recently starred in the Broadway play "Road to Mecca."
In her latest project, Gugino will play Pulitzer Prize-winning newspaper reporter Susan Berg, a hungry Washington journalist intent on destroying the career of former first lady and newly appointed Secretary of State Elaine Barrish, played by Weaver, a synopsis said.
"Political Animals" is to debut on the cable network this summer.
Celebrity Families of 2014 [PHOTOS]