James is best known for his work in the hit films "Paul Blart: Mall Cop" and "Hitch," as well as on the long-running TV comedy "The King of Queens."
"In short, I guess you could say hosting the Kids' Choice Awards completes me," People.com quoted James as saying Monday.
The 2010 Kids' Choice Awards show is scheduled for March 27.
Scarlett Johansson steps out with fiance after pregnancy reveal
Dennis Rodman pledges to end trips to North Korea