Fierstein, the author of the original production, is to start his 12-week engagement in the role of drag queen Albin on Feb. 15 at Manhattan's Longacre Theatre.
This marks the first time Fierstein will appear in the show.
Fierstein's co-star will be announced soon, the producers said.
The current stars of "La Cage," Kelsey Grammer as Georges and Douglas Hodge as Albin, will depart the production Feb. 13.
"I've loved watching this new production of 'La Cage' and think director Terry Johnson and the wonderful company at the Longacre have really mined the material for its humor as well as its heart and humanity," Fierstein said in a statement.
"I'm thrilled to get the chance to play Albin a mere 25 years after creating him. It will be a challenge to follow in the footsteps of all the brilliant actors who have portrayed the role before me. But I do have one secret weapon -- I know how to reach the author for rewrites."