The announcement was made Wednesday by producers Red Hour Films, Lauren Versel, Molly Hassell, Maria Teresa Arida and Lucky Monkey Pictures.
The movie is a modern-day tale of two young beautiful female vampires -- played by Alicia Silverstone and Krysten Ritter -- living the good nightlife in New York until love enters the picture and each has to make a choice that will jeopardize her immortality, the producers said in a news release.
The film also co-stars Sigourney Weaver, Richard Lewis, Wallace Shawn, Justin Kirk, Dan Stevens, Todd Barry and Kristen Johnston.
Henner will portray Angela, a deathly ill woman who gets "awakened" to her former hot self. Orth will portray Renfield, a young nerdy friend of Stacy (played by Ritter) and Goody (played by Silverstone,) who tries to be much tougher than he actually is. McDowell will portray vampire Vlad Tepish, otherwise known as the infamous Vlad the Impaler, who enjoys wearing velvet jogging suits and knitting.