The pair also both previously lent their voices to characters in the animated movie "The Polar Express," and appeared together in the film "That Thing You Do!"
Hanks, a double Oscar winner, will make his Broadway debut in "Lucky Guy," a play penned by his late friend Nora Ephron and directed by George C. Wolfe. Set in 1980s New York, it is about the charismatic and controversial tabloid columnist Mike McAlary.
Also starring in the play will be former "Newhart" cast member Scolari, as well as Christopher McDonald, Peter Gerety, Michael Gaston, Dustyn Gulledge, Deirdre Lovejoy, Danny Mastrogiorgio, Richard Masur and Stephen Tyrone Williams.
Additional casting will be announced soon, the show's producers said.
"Lucky Guy" will play a limited engagement at the Broadhurst Theatre, with an opening night set for April 1. Previews will begin March 1.