Laurie was scheduled to be on the "House" set Friday, but left Los Angeles Thursday night instead, Variety.com reported.
"Hugh had family obligations in England to attend to, but production is continuing in his absence," a representative for show producer Universal Media Studios said, adding that, per producers, Laurie "asked for time off and they were happy to facilitate it."
The move has sparked chatter that something is going on and that Laurie might not be happy, the trade paper said.
But Laurie's publicist said there is no reason to spin conspiracy theories about Laurie's absence.
"He'll be back on the set on Monday," she said.