Santiago Giraldo Salazar (born November 27, 1987) is a Colombian male tennis player from Pereira in Colombia. He plays on the ATP tour and represents Colombia in the Davis Cup competition.
Since turning professional in 2006, Santiago Giraldo has competed in lower events at Buenos Aries, Bogotá and Asunción. He reached the final at Bogotá in October 2007 but he lost out in straight sets. Giraldo reached his first Grand Slam main draw at the 2007 French Open, where he lost to Novak Djoković.
Santiago played in his first major non-Grand Slam singles tournament on 12–15 March 2008, the Masters Series Pacific Life Open, where he lost to then World No. 2 Rafael Nadal 6–3, 6–3, in the second round. He beat Werner Eschauer in the first round after coming through two rounds of qualifying. Giraldo then qualified for the 2008 Sony Ericsson Open, where he lost in round 1. He played in the 2008 French Open after the withdrawal of home-favourite Richard Gasquet through injury, but he lost in the first round against Florent Serra of France.