New York Giants wide receiver Odell Beckham Jr. will not play in Sunday's matchup against the Washington Redskins.

Buffalo Bills defensive end Jerry Hughes was fined $53,482 for unsportsmanlike conduct on Saturday in the wake of his confrontation with umpire Roy Ellison following last Sunday's game against the Miami Dolphins.

A highly efficient offense and an opportunistic defense ruined Richard Sherman's homecoming in Seattle as the Seahawks defeated the San Francisco 49ers.

Kansas City Chiefs quarterback Patrick Mahomes has been the talk of the NFL, and he will try to keep it going on Sunday against the San Francisco 49ers.

When the NFL's official injury report was released Friday for Sunday's games, 24 players were listed as out, but three key names were not among them.

The San Francisco 49ers placed linebacker Dekoda Watson on injured reserve, the team announced Saturday.

The Detroit Lions have acquired linebacker Eli Harold from the San Francisco 49ers in exchange for a future undisclosed draft pick.

The San Francisco 49ers won their preseason opener on Thursday night, but they came up short in an area that is of great importance to the coaching staff.

San Francisco 49ers defensive end Arik Armstead is expected to be sidelined week-to-week as he nurses a hamstring injury, the team announced Tuesday.

Defensive end Cliff Avril was waived on Friday by the Seattle Seahawks, with a failed physical designation, the team announced.

The San Francisco 49ers have more than enough available money to re-sign all six of their key unrestricted free agents.

Anyone claiming you can't learn a lot about a team in the preseason opener clearly wasn't watching the San Francisco 49ers against the Kansas City Chiefs.

The San Francisco 49ers aren't well equipped to lose many of their starters to injury.

Cornerback Asa Jackson has agreed to a contract with the San Francisco 49ers.

The San Francisco 49ers officially placed linebacker Malcolm Smith on the injured reserve list Monday with a torn pectoral muscle, ending his 2017 season.