Lucas John "Luke" Gregerson (born May 14, 1984 in Park Ridge, Illinois) is a Major League Baseball relief pitcher for the San Diego Padres. He owns the major league record for holds in a season.
Gregerson was drafted by the St. Louis Cardinals in the 28th round of the 2006 Major League Baseball Draft out of Saint Xavier University. He spent his first professional season between the Rookie-Level Johnson City Cardinals and the Short-Season State College Spikes in 2006. He went 0-1 with a 3.86 ERA in 15 games with Johnson City and 6-1 with a 1.72 ERA in 12 games with State College.
In 2007 Gregerson split the season between the Advanced-A Palm Beach Cardinals and the Double-A Springfield Cardinals. With Palm Beach he went 3-4 with a 1.97 ERA in 53 games and with Springfield he was perfect in only inning of work.