Luis Alberto Castillo (born August 4, 1983 in Brooklyn, New York), is a Dominican American football defensive end for the San Diego Chargers of the NFL. He was the cover athlete for the Spanish language version of Madden NFL 08.
Castillo attended Garfield High School in New Jersey, where he was team captain and team MVP of the football team.
He attended Northwestern University, where he lived in Elder Hall for his freshman year. He was a 2004 Pro Football Weekly All-American selection, a Second-team All-Big Ten, Academic All-America by ESPN and Second-team Academic All-Big Ten. In 2003 he was a First-team Academic All-District and Academic All-Big Ten. Again, a Second-team Academic All-District by CoSIDA and Academic All-Big Ten in 2002. Castillo finished career with 251 tackles, 4.5 sacks, and 19.5 tackles for loss.