An outstanding night by the San Francisco 49ers was tarnished by an ugly injury to Raheem Mostert.

The Arizona Cardinals and San Francisco 49ers are suffering through eerily similar seasons.

The San Francisco 49ers are off to a disastrous 1-6 start but coach Kyle Shanahan told reporters Monday that he is not deviating from his plan to make the franchise relevant again in the NFL.

The San Francisco 49ers have been without their top three offensive skill players for the bulk of the season.

It has been three years since the San Francisco 49ers and Green Bay Packers have squared off, but the teams will hook up Monday night at Lambeau Field.

The San Francisco 49ers could be without key players on both sides of the ball for Sunday's game against the visiting Arizona Cardinals.

The San Francisco 49ers traded for Jimmy Garoppolo midway in the 2017 season in what they hoped would be the first building block to turn around the franchise.

Franchise quarterback Jimmy Garoppolo is feared to have suffered a torn ACL in the San Francisco 49ers' loss to the Kansas City Chiefs at Arrowhead Stadium.

The San Francisco 49ers entered the season with some questions about their ground game after starting running back Jerick McKinnon suffered an ACL injury in practice before the season began. Some of those concerns were allayed in Sunday's 30-27 victory over the Detroit Lions.

Defensive end Khalil Mack and the Chicago Bears reached agreement on a six-year, $141-million deal Saturday that makes Mack the highest paid defensive player in the history of the NFL.

San Francisco 49ers running back Jerick McKinnon sustained a torn ACL, according to multiple sources, on the final play of practice Saturday and will be lost for the season.

Pittsburgh Steelers star Le'Veon Bell and Los Angeles Rams star Todd Gurley lead UPI's top 150 player rankings for the 2018 fantasy football season.

The San Francisco 49ers have signed running back Ja'Quan Gardner and waives safety Chanceller James.

Dynamic Pittsburgh Steelers star Le'Veon Bell tops UPI's top 100 fantasy football running backs for the 2018 season.

San Francisco 49ers running back Jerick McKinnon will sit out the remainder of the preseason.