The prince will also visit occupied Palestinian territories. Wednesday, he will meet with Palestinian Authority President Mahmoud Abbas in Ramallah in the West Bank.
Earlier Tuesday, William started his tour with a visit to the Yad Vashem Holocaust Museum in Jerusalem, where he spoke with survivors and laid a wreath at the Hall of Remembrance.
He also met with Edith and Phillipe Cohen, two descendants of victims sheltered by Princess Alice, William's great-grandmother, during the Holocaust.
Monday, William toured Jordan and visited the archaeological ruins of Jerash, a Roman city dating to the first century.
William also met with Sara Netanyahu Tuesday, who was indicted last week on fraud charges.