The Grand Slam tournament draw came out Thursday.
On the women's side, Serena Williams returns and is actually seeking her eight title. She was on leave last season after having a baby. Williams is seeded 16th this time, and in the same bracket as top-ranked Simona Halep. They could meet in the fourth round.
Meanwhile, Djokovic is No. 1 on the men's side and his biggest test before a semifinal could be No. 8 Kei Nishikori.
Federer, last year's champion, is in the bottom half of the draw with second-ranked Rafael Nadal.
The Open runs from Jan. 14-28.