San Francisco 49ers quarterback Trey Lance, shown Oct. 3, will be the fourth-youngest quarterback at the time of his first start in the NFL on Sunday against the Arizona Cardinals. Photo by Terry Schmitt/UPI | License Photo
Oct. 8 (UPI) -- San Francisco 49ers rookie quarterback Trey Lance will make his first NFL start against the Arizona Cardinals on Sunday.
Niners head coach Kyle Shanahan told reporters Friday that Lance will replace injured signal-caller Jimmy Garoppolo this week. That announcement comes after Lance took the reps with the first-team offense throughout the week as Garoppolo deals with a strained and bruised right calf.
Garoppolo was listed as out on the 49ers' final injury report after he failed to practice all week. Veteran Nate Sudfeld is expected to be elevated from the practice squad to serve as the backup to Lance.
Lance, who will be 21 years and 154 days old Sunday, will be the fourth-youngest quarterback in league history at the time of his first start in the NFL.
"Just with this being his first start, just trying to give him stuff he's comfortable with, stuff we've put him through," Shanahan said of his plans for Lance against the undefeated Cardinals. "You don't want to sit there and make up too much new stuff. There's only a couple days of practice, you just want to make sure he's as comfortable as possible."
Lance completed 50% of his passes for 157 yards with two touchdowns last week against the Seattle Seahawks. He also ran seven times for 41 yards in the Niners' 28-21 loss to Seattle.
Garoppolo is expected to be a pre-game inactive for the 49ers on Sunday, but with San Francisco entering its bye in Week 6, the team hopes he can return for the Oct. 24 matchup against the Indianapolis Colts.
Los Angeles Chargers quarterback Justin Herbert waves his fist to the crowd after a 28-14 victory over the Las Vegas Raiders at SoFi Stadium in Inglewood, Calif., on Monday. Photo by Jon SooHoo/UPI | License Photo