"He's looked good. He feels good," Payton said. "We were encouraged at the start of the week. We wanted to see how it felt as he went through a full practice week, and he's done a good job."
The Saints believe Brees is fully healthy and doctors have cleared him to compete, according to ESPN. The 41-year-old quarterback returned to practice this week after missing the past four games due to 11 broken ribs and a punctured lung.
"We wouldn't be playing him if he wasn't healthy and able to function and feeling good and recovered," Payton said.
With Brees back in the lineup, veteran signal-caller Jameis Winston will serve as the Saints' No. 2 quarterback. Taysom Hill, who filled in for Brees and posted a 3-1 record as the team's starter, will play his jack-of-all-trades role, including some snaps at quarterback.
Meanwhile, the Saints ruled out Pro Bowl wide receiver Michael Thomas on Friday. The star wideout didn't practice all week because of a lingering ankle injury.
Thomas had played through the ailment since returning to the Saints' starting lineup in Week 9.
The Saints (10-3) will host the Chiefs (12-1) at 4:25 p.m. EST Sunday at the Mercedes-Benz Superdome in New Orleans.