With under 10 minutes left before halftime, Coleman fell awkwardly on his right arm after he was brought down by Packers safety Adrian Amos on a 4-yard run. Coleman immediately appeared to be in pain as the 49ers' training staff rushed onto the field.
After a few minutes on the field, Coleman was able to stand up but failed to walk off under his own power. He was taken to the locker room on a cart and later ruled out for the rest of the game.
Coleman finished with 21 yards on six carries in the first half. In his absence, Raheem Mostert picked up 160 yards and three touchdowns on 14 carries before halftime.
The 49ers held a 27-0 lead over the Packers at halftime.