With the Cardinals holding a 17-7 lead, Murray appeared to injure his right hamstring on a 4-yard scamper in the third quarter. On a third-and-12 play, he scrambled to the left and was pushed out of bounds near the Seahawks' sideline.
Murray was seen walking with a slight limp on the sideline and later had his right hamstring wrapped. The team officially ruled the quarterback as questionable to return, but the first-overall pick in the 2019 NFL Draft never made it back on the field.
Brett Hundley replaced Murray and completed 4-of-9 passes for 49 yards, while adding 35 rushing yards on six carries. He guided the Cardinals on a late touchdown drive in the fourth quarter to clinch the win.
Prior to his injury, Murray completed 11-of-18 throws for 118 yards and a touchdown. He contributed 40 rushing yards on six carries.
Murray previously was listed with a hamstring injury in Week 13 but didn't miss any time. The Cardinals (5-9-1) will close the season against the Los Angeles Rams next Sunday.