The team announced Friday that Damien Williams was ruled out against the Patriots because of a rib injury. Earlier in the week, the Chiefs placed Darrel Williams on injured reserve with a hamstring injury.
The injuries leave the Chiefs with rookie Darwin Thompson and veterans LeSean McCoy and Spencer Ware in the backfield. McCoy currently leads the team in rushing yards (410), while Thompson had his first extending playing time during last week's 40-9 blowout win over the Oakland Raiders.
The Chiefs signed Ware, who played in Kansas City from 2015 through last season, earlier this week. He led the team in rushing during the 2016 campaign.
The Chiefs (8-4), holding a two-game lead over the Raiders in the AFC West, will play the Patriots (10-2) at 4:25 p.m. ET Sunday at Gillette Stadium in Foxborough, Mass.