The team announced Sunday that Thielen was ruled out for Monday's matchup at CenturyLink Field in Seattle because of a hamstring injury. League sources told ESPN that the wideout didn't travel with the team and will remain in Minnesota.
It will mark the third consecutive game that Thielen will miss due to his hamstring issue. He expressed optimism about his progress after the Vikings' Week 12 bye, but told reporters Friday that he won't play if his hamstring isn't 100 percent.
"Just because I know that if you're not 100 percent, you're going to come out five plays into the game anyways," Thielen said. "That's probably the biggest difference of a hamstring from a different injury, is you can play through pain with other injuries.
"But as I found out quickly with a hamstring, if you feel any pain, eventually it's just not going to work. So that's kind of the plan right now."
Thielen, a two-time Pro Bowl selection, has been dealing with the hamstring injury in his right leg since the middle of October. He initially suffered the injury against the Detroit Lions on Oct. 20 and immediately exited the game.
Thielen missed the Vikings' Week 8 game against the Washington Redskins and made a brief return in Week 9 against the Kansas City Chiefs before aggravating his injury early in the contest. He hasn't played since Week 9.
In eight games this season, Thielen has recorded 27 receptions for 391 yards and six touchdowns.