Mahomes declared himself healthy Friday after being a full participant in practice throughout the week. He was listed without an injury designation, according to the team's official injury report.
"I'm feeling good. I had a good week of practice," Mahomes told reporters after the Chiefs' practice on Friday. "I'm ready to get out there."
Mahomes hasn't played since suffering a dislocated right kneecap during the Chiefs' 30-6 win over the Denver Broncos on Oct. 17. The gunslinger hasn't missed a practice but returned in a full capacity and took first-team reps for the first time this week.
Mahomes, the NFL's reigning MVP, said doctors told him at the beginning of the week he had a chance to suit up against the Titans.
"I knew I had a chance once I talked to those doctors and they said as long as I was functioning well, moving well, I could play this week," Mahomes said. "Coach [Andy] Reid still wanted me to take it day by day. I went out here in practice and took the reps and I haven't had any pain or any setbacks, and so as long as we keep going with that I'm glad to be back out there."
Mahomes has completed 157-of-241 passes for 2,180 yards, 15 touchdowns and one interception in seven games this season.