First-round pick N'Keal Harry and former Miami Hurricanes wide receiver Braxton Berrios are candidates to see increased snaps with Edelman out, according to ESPN.
Edelman has recorded 499 passes for 5,390 yards and 30 touchdowns since debuting in 2009. He caught 74 passes for 850 yards and six touchdowns in 12 games last year.
Edelman added 26 receptions for 388 yards in the playoffs. He was named MVP of Super Bowl LIII in February.
New England opens its season against the Pittsburgh Steelers in Foxboro, Mass., on Sept. 8.