Coach Matt Nagy said on Tuesday that Trubisky is day-to-day with a right shoulder injury. The 24-year-old Trubisky sustained the injury following a late hit by safety Harrison Smith during the fourth quarter of Sunday night's 25-20 win over the Minnesota Vikings.
"I'm staying cautiously optimistic, but I can't make any promises," Nagy said. "I hope he does. ... He wants to play, I know that. We've got to make sure in these situations we're doing the right thing."
Chase Daniel would be in line to start if Trubisky is unable to face the Lions (4-6).
The Bears (7-3) are in the midst of a short turnaround, as they put their flexed Sunday night game in the past and focus on their 12:30 p.m. ET contest at Ford Field.
Trubisky threw for 165 yards and rushed for 43 more versus the Vikings. He threw for a season-high 355 yards with three touchdowns in Chicago's 34-22 victory over Detroit on Nov. 11.
The 6-foot-3, 222-pound Trubisky has thrown for 2,469 yards with 20 touchdowns and nine interceptions in 10 games this season. He has completed 406 of 651 passes for 4,662 yards with 27 touchdowns and 16 interceptions in 22 career contests since being selected by the Bears with the second overall pick of the 2017 NFL Draft.