Trailing 24-0 in the final moments, Tennessee's quarterback was sacked for the fourth time and suffered an apparent elbow injury.
The Titans said his return was questionable. He was replaced by Blaine Gabbert.
Tennessee also reported that defensive coordinator Dean Pees was taken from the stadium early in the game after suffering a stroke.
Pees, 69, is in his first season with the Titans. He came out of retirement to join Mike Vrabel's staff.