However, Gruden said on Thursday that Williams was scheduled to see a specialist about his injury.
That visit will determine whether Williams needs surgery to repair the injury, and it will help Williams decide whether he can play with a cast on his hand. A decision on Williams' status is expected to be made on Friday.
Williams has been named to the Pro Bowl each of the past six seasons and has made 113 NFL starts. The 30-year-old Williams was the fourth overall pick in the 2010 NFL Draft.
If Williams cannot play, Ty Nsekhe would start in Williams' place. The 33-year-old Nsekhe has played in seven games this season but has not started any. He has made 11 starts in his NFL career, and this is his fourth season with the Redskins.